What is the immunological marker associated with a resolved Hepatitis B infection?

The presence of Anti-HBs (antibodies against the Hepatitis B surface antigen) indicates recovery and immunity from a Hepatitis B infection. Specifically, when an individual has cleared the infection, Anti-HBs is produced, signifying that the body has mounted an effective immune response against the virus.

Additionally, the presence of Anti-HBc (IgG) indicates past infection and is commonly found alongside Anti-HBs in individuals who have resolved their Hepatitis B infection. This combination of markers is indicative of a previous Hepatitis B infection that has been effectively cleared, and the individual now possesses immunity, either through successful resolution or through vaccination.

In contrast, other markers presented in the options relate to active infection or earlier phases of Hepatitis B infection. HBsAg indicates active hepatitis infection, HBeAg corresponds to the replication of the virus, and Anti-HBc (IgM) signifies recent infection, typically indicating the acute phase of the disease. Thus, the combination of Anti-HBs and Anti-HBc (IgG) specifically clarifies that the infection has resolved and the individual has developed lasting immunity.