What is the standard duration of antibiotic therapy for infective endocarditis?

The standard duration of antibiotic therapy for infective endocarditis is typically 4 to 6 weeks, depending on the specific pathogen involved, the severity of the condition, and the patient's clinical response. However, 4 weeks is often considered the minimum duration for uncomplicated cases, especially for infections caused by certain organisms such as Streptococcus viridans, particularly when there are no complications.

In cases of infective endocarditis due to more aggressive bacteria or in the presence of prosthetic heart valves, longer therapy may be indicated. For example, certain highly virulent organisms or complicated cases might necessitate an extended duration of up to 6 weeks or more. Therefore, while the choice of 4 weeks is appropriate for many cases, it's essential to consider the context and specific details of each case regarding the total duration of therapy. This approach ensures an effective resolution of the infection while reducing the chance of recurrence or complications.