Which of the following is a symptom of ALL (Acute Lymphoblastic Leukemia)?

Fatigue and bone pain are indeed common symptoms of Acute Lymphoblastic Leukemia (ALL). This condition is characterized by the proliferation of lymphoblasts, which are immature white blood cells that interfere with the normal function of blood cells. As a result, patients often experience fatigue due to anemia, which is a reduction in red blood cells responsible for carrying oxygen throughout the body. Bone pain occurs as a result of the accumulation of leukemic cells in the bone marrow, leading to increased pressure in the marrow spaces and causing discomfort.

While painless lymphadenopathy, splenomegaly, and hypercalcemia can also be associated with various hematological disorders, they are not as specific to ALL. Painless lymphadenopathy typically occurs in a range of conditions, including lymphoma. Splenomegaly can be seen in multiple forms of leukemia and other diseases, and hypercalcemia is more commonly associated with malignancies like primary hyperparathyroidism or metastatic bone disease rather than ALL specifically. Thus, the combination of fatigue and bone pain stands out as hallmark symptoms directly related to the pathophysiology of Acute Lymphoblastic Leukemia.